In recent years, technologies make it possible to obtain genetic data very easily and studies that investigate the contribution of the genetic component in different clinical fields have become very common. However, although it is easy to obtain genetic data, it is necessary to have specific skills to draw correctly research protocols and data analysis The aim of the course is to describe how epidemiological studies in the genetic field are conducted. The course aims to be transversal and to provide useful skills in all areas that has to do with genetic data and the need to process and manage it. For this reason the course aims to be useful for Life Sciences, Bioengineering and Bionformatics phd Programs

Day 1

• -10.00 Introduction of the course
• -10,30 Genetics of Complex Diseases
• -11.30 Genetic Variability
• -12.30 Lunch
• -13.30 Linkage Disequilibrium
• -14.30 Break
• -15.00 The Pedigree file and Plink
• -15.30 LABORATORY 1: Exercises with the Disequilibrium linkage with Haploview and Plink
• – Summary of the main concepts

Day 2

• -9.30 The Likelihood
• -10,30 The analysis of Parametric Linkage
• -11.30 LABORATORY 2: Exercises with Parametric Linkage
• -12.30 Lunch
• -14.00 The analysis of multi-locus linkage with Merlin
• -15.00 Break
• -16,00 LABORATORY 3: Exercises with the multi-locus Parametric Linkage with Merlin
• – Summary of the main concepts

Day 3

• -9.30 Complex Diseases and Case Control Association Studies
• -10,30 Analysis of association and transmission models
• -12.30 Lunch
• -13.30 LABORATORY 4: Exercises Studies association with R
• – Summary of the main concepts

Day 4

• -9.30 Association Analysis for Family Studies
• -10,30 TDT Analysis and Conditional Logistic Regression
• -12.30 Lunch
• -13.30 LABORATORY 5: Exercises Studies Family association with R
• – Summary of the main concepts

Day 5

-9.30 Non-Parametric Linkage Analysis

-10.30 Homozygosity Haplotype Analysis

-11.30 IBD sharing Analysis and LOH Analysis

-12.30 Lunch

-13.30 LABORATORY 6: Homozygosity Haplotype Analysis exercise

-15.00 Break

-16,00 LABORATORY 7 IBD Analysis and LOH Analysis exercise

– Summary of the main concepts